There are a lot of things that one need to know about COMT. The first important thing that a person should know about COMT is that it is an official symbol for the gene called catechol O methyltransferase. To make an enzyme, you need to know that COMT is one of the genes responsible for making catechol O methyltransferase. There are two type of catechol O methyltransferase enzyme that you should know about. There is a longer form of the enzyme that is produced by the brain cells. For the shorter enzymes, you get to have other part of the body producing it. Some of the body parts that produce shorter enzymes include liver, blood and kidney. The shorter enzymes are very important in the body in that there are responsible in controlling some of the body hormones. There are chemical messages that are found in the brain that are broken down by the catechol O methyltransferase. The chemical messengers in the brain are responsible in transfer of information from nerve cell to another. Take a look at this website for more details about the catechol O methyltransferase enzyme.
Prefrontal cortex is the part of the brain that is found in front of the head where you get most of the importance of catechol O methyltransferase. Prefrontal cortex is used to coordinate and organize the information found on the other part of the brain. Some of the things that the above named region is responsible for include working short term memory, inhibition of behavior and personality. The main thing that need to be present for the prefrontal to work properly is neurotransmitters. The most important neurotransmitters that you need to know about include norepinephrine and dopamine.
There are a lot of drug structures that you can get catechol O methyltransferase hence one of the few enzymes that can degrade catecholamine. The encoding of the COMT gene in human being is through catechol O methyltransferase protein. There are two type pf isoforms that are produced for COMT that are called the membrane bound long form and the soluble short form. For more details about this enzyme, view here: https://umbrella-scientific.us/product/catechol-o-methyltransferase-comt/.
According to the research, you get to know that COMT plays an important role in oestrogen in terms of metabolism. Through in activities of something called catecholestrogens, you get to have COMT involved in oestrogen. When some of the oestrogen such as estradiol are metabolised, you get to have the formation of catecholestrogen. For the cancer causing proteins, you get to have owe activity. To get a detailed overview of this topic, see here: https://en.wikipedia.org/wiki/Catechol-O-methyltransferase .